TheResident Evilseries has been around for decades, spawning multiple games, both mainline and spin-off. While story and character development has never been a major focus point in the franchise, many characters have become iconic and beloved.
Due to the extensiveness of the games, there is a vast number of playable characters throughout the franchise. Even within the bracket of what would be considered as major playable characters, all have different fates after their time in their respective games. Some have more information on what happens to them, while others' stories are left open-ended.

Rose is the most recent playable DLC character, but more importantly, she is the driving figure behind the story ofResident Evil Village.Having been abducted, her father, Ethan Winters, rescues her. Later, Rose starred in her own DLC, with some peoplewanting her in a standalone game.
In the DLC, Rose accepts Chris Redfield’s offer to be a part of his operation at the Bioterroism Security Assessment Alliance. With her powers, she is a valuable asset. Maybe in fifteen years, when the DLC canonically takes place, Rose might return to theResident Evilseries.

The closest to an antagonist theResident Evilseries got was Albert Wesker. Of course, his son also had a prominent role in the franchise. Jake Muller was introduced in his own campaign along with Sherry Birkin inRE6.
Working as a mercenary, Jake was vital toRE6,as his blood was able to create a vaccine for the C-Virus. After the events of the game, he donated his blood. He then began fighting bio-organic weapons in other countries, still as a mercenary.

12Helena Harper
Absolved Of Her Crimes
Resident Evil 6didn’t receive high praise when it was released. This could be a factor in the lack of information regarding Helena’s whereabouts after the game.
InRE6,she appeared as a joint character alongside Leon S. Kennedy as a United States Secret Service member. Framed for the murder of the American President by Derek C. Simmons, Helena’s journey was mainly targeted at him in revenge for her sister. After the events of the game, Helena was absolved of criminal wrongdoings and was allowed to join the team once more.

11Piers Nivans
Sacrificed Himself To Save Chris
Piers only appeared inResident Evil 6as a result of what happened to him. He is available as the partner character in Chris Redfield’s campaign inRE6.
After nearly dying, he infected himself with the C-Virus, enabling him to stay alive to kill a bioweapon. He stayed behind while he still possessed sentience, which allowed Chris to escape in an escape pod. Despite his story ending shortly, the ripples Piers left can still be seen in later games. Chris stays in the BSAA and becomes more jaded after seeing his partner die.

Sherry has one of the wildest backstories inResident Evil.Introduced inRE2, she survived the Raccoon City Incident as a child. She was infected by a G-Virus embryo, with her parents being responsible for the horrors she went through. Years later, she became a Division of Security Operations agent, and was involved in the events ofRE6.Thanks to her involvement with Jake Muller, the C-Virus outbreak was contained.
There isn’t much information to go on compared to some of the better-known characters in theResident Eviluniverse. However, most assume that Sherry continues to work for the DSO.

Resident Evil 5didn’t garner as much praise as its predecessors did. As a result, Sheva hasn’t appeared much after the events in Africa.
Introduced as a member of the West African division of the BSAA, Sheva returned to working as a part of the organization. A few years after the events ofRE5, Sheva expressed worries at Chris Redfield’s disappearance to Piers Nivans. WithRE5next in line for the remake treatment, maybe players will get to see Sheva again, especially since theSeparate Ways DLC can bridge the gap between games.

Resident Evilisn’t the happiest series. Characters that haven’t been seen for a while are most likely living a normal life. Such is the case with Billy, who appeared for the first and last time inRE0as a joint playable character alongside Rebecca Chambers.
Framed for murder before the events ofRE0, Rebecca finds out that Billy is innocent. They say goodbye at the end of the game, with Rebecca reporting that Billy has died, with his whereabouts currently unknown. However, since the destruction of Raccoon City, all documents of Billy are most likely destroyed, leaving him free.

Rebecca was introduced in the firstResident Eviland became a playable character inRE0.She was one of the youngest characters featured, being only eighteen while killing bioweapons.
Despite being well-liked, Rebecca has mostly remained in the background ofResident Evil. However, she was still a valuable asset to the BSAA. She also held roles at various universities, thanks to her smarts. Regardless of her time spent behind the scenes working the scientific route, she’s still capable of holding her own against zombies and other monsters.

6Ada Wong
A Mysterious Character With A Mysterious Fate
Ada hasn’t had a definitive game where she plays the central role as a protagonist, except forResident Evil 4’s Separate Ways DLC. However, she has made multiple appearances throughout theResident Evilseries as a playable character. She usually appears where Leon S. Kennedy is, as a mysterious spy with a hidden agenda.
Fighting against any bioweapons that get in her way, she was employed by a rival company to Umbrella, and later, Albert Wesker. In her last chronological appearance inRE6, she accepted a new job, leaving her fate ambiguous.

Despite being a very popularResident Evilcharacter,Claire has only appeared in a few mainline games;RE2andRE: Code Veronica. The sister of Chris Redfield, Claire has also devoted her life to stopping bioterrorism.
After the events ofRE2,Claire appeared inCode Veronica.In the following years, she would become a member of TerraSave, helping those who were affected by bioterrorism. However, being a Redfield, she would still battle any bioweapons that got in her way.